反应详情

温度

30 °C

1-(2-chlorobenzyl)-5-bromoindoline-2,3-dione (0.175 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 24 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

1. extractionThe obtained product was extracted with ethyl acetate
2. custompurified by silica gel column chromatography
3. customto afford pure product