Nitromethane → HCID 72709757, compound

HRID 1427696Notes

Reaction equation

HRID 1427696 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([Br:14])=[CH:11][CH:12]=2)[C:7](=[O:15])[C:6]1=[O:16].[N+:21]([CH3:24])([O-:23])=[O:22]>O>[Br:14][C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][CH:11]=1)[N:5]([CH2:4][C:3]1[CH:17]=[CH:18][CH:19]=[CH:20][C:2]=1[Cl:1])[C:6](=[O:16])[C:7]2([OH:15])[CH2:24][N+:21]([O-:23])=[O:22]

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 2196908HCID 2196908, compound

Product 1

HCID 72709757HCID 72709757, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

1-(2-chlorobenzyl)-5-bromoindoline-2,3-dione (0.175 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 24 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Workup

  1. extractionThe obtained product was extracted with ethyl acetate
  2. custompurified by silica gel column chromatography
  3. customto afford pure product

Sources & evidence

ORD record
ord-a6701989f1a447a1be36c587bb9e18b7
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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