Ethanol → HCID 178510410, compound

HRID 1428040Notes

Reaction equation

HRID 1428040 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]3[NH:27][CH:28]=[C:29]([C:31]#[N:32])[N:30]=3)=[O:25])=[C:19]([C:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH:34]=3)[CH:18]=2)[CH2:13][CH2:12]1)=[O:10])(C)(C)C.CCO.[C:43]([OH:49])([C:45]([F:48])([F:47])[F:46])=[O:44]>C(Cl)Cl>[F:46][C:45]([F:48])([F:47])[C:43]([OH:49])=[O:44].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]3[NH:27][CH:28]=[C:29]([C:31]#[N:32])[N:30]=3)=[O:25])=[C:19]([C:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH:34]=3)[CH:18]=2)[CH2:13][CH2:12]1)=[O:10]

Participants

5

Reactant 3

HCID 702EthanolHCID 6422Trifluoroacetic acidHCID 178453786HCID 178453786, compound

Product 1

HCID 178510410HCID 178510410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [2-(4-{4-[(4-cyano-1H-imidazole-2-carbonyl)-amino]-3-cyclohex-1-enyl-phenyl}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (as prepared in the previous step, 0.41 g, 0.77 mmol) in CH2Cl2 (20 mL) was treated with EtOH (0.2 mL) and TFA (6 mL). The mixture stirred at room temperature for 45 min, and the solvents were evaporated in vacuo. The crude material was used directly in the next step. LC-MS (ESI, m/z): Calcd. for C24H28N6O2 433.2 (M+H). found 433.2.

Workup

  1. customthe solvents were evaporated in vacuo

Sources & evidence

ORD record
ord-0d68bc8921ef465caac19c72a23130e7
Source dataset
uspto-grants-2015_01
Patent number
US08933091B2

Reaction notes

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