Acetone → HCID 86700083, compound

Participants

Reaction Conditions

Reaction Steps

Acetone (3.0 ml), water (1.87 ml) and a 1.004 mol/L aqueous hydrochloric acid solution (2.70 ml, 1.10 eq.) were added to N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide (1.52 g, 2.46 mmol) at room temperature. The mixture was stirred at 40° C. for about 11 hours and then stirred at room temperature for about 30 minutes, and the precipitated solid was collected by filtration. The solid was then dried under reduced pressure at room temperature for about three hours to give the title compound (1.60 g). Yield: 94%.

Provenance & Evidence