Acetone → HCID 86700083, compound

HRID 1428132Notes

Reaction equation

CC(C)=[O:3].[ClH:5].[NH2:6][C:7]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20]([C:22]3[C:27](=[O:28])[C:26]([C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)=[CH:25][N:24]([CH2:36][C:37]([F:40])([F:39])[F:38])[CH:23]=3)=[O:21])=[CH:15][CH:14]=2)=[CH:11][C:10]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([O:49][CH3:50])[CH:42]=2)=[CH:9][N:8]=1>O>[OH2:3].[OH2:21].[ClH:5].[NH2:6][C:7]1[C:12]([C:13]2[CH:14]=[CH:15][C:16]([NH:19][C:20]([C:22]3[C:27](=[O:28])[C:26]([C:29]4[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=4)=[CH:25][N:24]([CH2:36][C:37]([F:38])([F:39])[F:40])[CH:23]=3)=[O:21])=[CH:17][CH:18]=2)=[CH:11][C:10]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([O:49][CH3:50])[CH:42]=2)=[CH:9][N:8]=1

Participants

Conditions

Temperature: 40 °C

Procedure

Acetone (3.0 ml), water (1.87 ml) and a 1.004 mol/L aqueous hydrochloric acid solution (2.70 ml, 1.10 eq.) were added to N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide (1.52 g, 2.46 mmol) at room temperature. The mixture was stirred at 40° C. for about 11 hours and then stirred at room temperature for about 30 minutes, and the precipitated solid was collected by filtration. The solid was then dried under reduced pressure at room temperature for about three hours to give the title compound (1.60 g). Yield: 94%.

Workup

stirringstirred at room temperature for about 30 minutes
filtrationthe precipitated solid was collected by filtration
customThe solid was then dried under reduced pressure at room temperature for about three hours

Sources & evidence

ORD record: ord-e668f430cdd5404c8ec876fad749f965
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08933103B2

Reaction notes

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