HCID 46941734, compound → HCID 46941735, compound

HRID 1428180Notes

Reaction equation

HRID 1428180 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([CH2:15][OH:16])=[CH:13][N:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:14]([CH:15]=[O:16])=[CH:13][N:12]=[CH:11][N:10]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 46941734HCID 46941734, compound

Product 1

HCID 46941735HCID 46941735, compoundYield 62.4%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of [4-(4-methoxyphenyl)pyrimidin-5-yl]methanol (8.6 g), manganese dioxide (48 g) and tetrahydrofuran (300 mL) was stirred overnight at room temperature. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (5.32 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-31274b100f654e0fa81ce1919b7699b6
Source dataset
uspto-grants-2015_01
Patent number
US08937055B2

Reaction notes

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