反应详情

温度

40 °C

To a 50 ml flask was added Nilotinib base (0.5 g, 0.94 mmol) and 2,2,2-trifluoroethanol (TFE) (5 ml). A clear solution was obtained. Fumaric acid (0.11 g, 1.03 mmol) was added, and the reaction was stirred at 40° C. for 1 hour. Then it was cooled to room temperature (20-30° C.) and stirred for 2 days. The solvent was then evaporated. A thick yellow paste was obtained, which was dried in a vacuum oven at 60° C. for 2 days to give Nilotinib fumarate form I.

1. customA clear solution was obtained
2. temperatureThen it was cooled to room temperature (20-30° C.)
3. stirringstirred for 2 days
4. customThe solvent was then evaporated
5. customA thick yellow paste was obtained
6. customwhich was dried in a vacuum oven at 60° C. for 2 days