Palmitic Acid → HCID 86688191, compound

Participants

Reaction Conditions

Reaction Steps

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. The stirred mixture was added to a solution of palmitic acid (0.145 g, 0.57 mmol) in TFE (1 mL) at 40° C. The resulting clear solution was stirred for about 4 h at 40° C. and it was subsequently cooled to 5° C. and kept at this temperature overnight to obtain a precipitate The precipitate was filtered and the filter cake was dried at 40° C. in a vacuum oven overnight to give Nilotinib palmitate form I.

Provenance & Evidence