Palmitic Acid → HCID 86688191, compound

HRID 1428285Notes

Reaction equation

HRID 1428285 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:21]([NH:23][C:24]2[CH:25]=[C:26]([C:36]([F:39])([F:38])[F:37])[CH:27]=[C:28]([N:30]3[CH:34]=[N:33][C:32]([CH3:35])=[CH:31]3)[CH:29]=2)=[O:22])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[C:40]([OH:57])(=[O:56])[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:21]([NH:23][C:24]2[CH:25]=[C:26]([C:36]([F:38])([F:39])[F:37])[CH:27]=[C:28]([N:30]3[CH:34]=[N:33][C:32]([CH3:35])=[CH:31]3)[CH:29]=2)=[O:22])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[C:40]([O-:57])(=[O:56])[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55]

Participants

3

Reactant 2

HCID 985Palmitic AcidHCID 644241Nilotinib

Product 1

HCID 86688191HCID 86688191, compound

Conditions

Temperature
40 °C

Procedure

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. The stirred mixture was added to a solution of palmitic acid (0.145 g, 0.57 mmol) in TFE (1 mL) at 40° C. The resulting clear solution was stirred for about 4 h at 40° C. and it was subsequently cooled to 5° C. and kept at this temperature overnight to obtain a precipitate The precipitate was filtered and the filter cake was dried at 40° C. in a vacuum oven overnight to give Nilotinib palmitate form I.

Workup

  1. temperatureit was subsequently cooled to 5° C.
  2. customkept at this temperature overnight
  3. customto obtain a precipitate The precipitate
  4. filtrationwas filtered
  5. customthe filter cake was dried at 40° C. in a vacuum oven overnight

Sources & evidence

ORD record
ord-c8009b791c8e42939e9274f779fd5187
Source dataset
uspto-grants-2015_01
Patent number
US08937082B2

Reaction notes

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