Beta-Alanine → HCID 753848, compound

HRID 1428420Notes

Reaction equation

HRID 1428420 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5].[OH-].[Na+].Cl.[C:10](Cl)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[N:13][CH:12]=1>O>[C:10]([NH:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[N:13][CH:12]=1

Participants

5

Reactant 3

HCID 239Beta-AlanineHCID 14798Sodium HydroxideHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

Product 1

HCID 753848HCID 753848, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ten grams of β-alanine and 9 g of sodium hydroxide were dissolved in 100 mL of purified water, and 18.15 g of nicotinoyl chloride hydrochloride were added dropwise under freezing conditions. After stirring for five hours, the product was filtered, the resulting crude product was recrystallized with aqueous ethanol, and 19.1 g of the desired product was obtained (yield of 84%).

Workup

  1. filtrationthe product was filtered
  2. customthe resulting crude product was recrystallized with aqueous ethanol

Sources & evidence

ORD record
ord-e74d605f20214c7ea061bfce95ab8828
Source dataset
uspto-grants-2015_01
Patent number
US08937090B2

Reaction notes

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