HuagongsheHuagongshe Chemistry Print Report · For research reference only
Beta-Alanine → 3-[(Pyridine-3-carbonyl)-amino]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Beta-Alanine | HCID 239 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[(Pyridine-3-carbonyl)-amino]-propionic acid | HCID 753848 | 96.5% |
Reaction Steps
Ten grams of β-alanine and 9 g of sodium hydroxide were dissolved in 100 mL of purified water, and 18.15 g of nicotinoyl chloride hydrochloride were added dropwise under freezing conditions. After stirring for five hours, the product was filtered, the resulting crude product was recrystallized with aqueous ethanol, and 19.1 g of the desired product was obtained (yield of 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937090B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-e74d605f20214c7ea061bfce95ab8828 |
| Source note | uspto-grants-2015_01 |