HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Chloro-4'-fluoropropiophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Fluorobenzene | HCID 10008 | — |
| Reactant | 5-Chlorovaleryl chloride | HCID 74089 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Nitrobenzene | HCID 7416 | — |
| Product | 2-Chloro-4'-fluoropropiophenone | HCID 67672 | 26.4% |
Reaction Steps
2-chloroethylpropionyl chloride (0.63 g), fluorobenzene (0.48 g), and aluminium chloride (0.8 g) were reacted in nitrobenzene (2.3 mL) at 0° C., followed by treatment with hydrochloric acid to obtain the title compound (0.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937091B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-3b7d027b8b1f4ee8b222a431fe14f948 |
| Source note | uspto-grants-2015_01 |