Hydrochloric Acid → 2-Chloro-4'-fluoropropiophenone

HRID 1428431Notes

Reaction equation

HRID 1428431 reaction equation
ClCC[CH2:4][CH2:5][C:6](Cl)=[O:7].[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Cl-:16].[Al+3].[Cl-].[Cl-].Cl>[N+](C1C=CC=CC=1)([O-])=O>[Cl:16][CH2:4][CH2:5][C:6]([C:13]1[CH:14]=[CH:15][C:10]([F:9])=[CH:11][CH:12]=1)=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 10008FluorobenzeneHCID 740895-Chlorovaleryl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 676722-Chloro-4'-fluoropropiophenoneYield 26.4%

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Procedure

2-chloroethylpropionyl chloride (0.63 g), fluorobenzene (0.48 g), and aluminium chloride (0.8 g) were reacted in nitrobenzene (2.3 mL) at 0° C., followed by treatment with hydrochloric acid to obtain the title compound (0.2 g).

Sources & evidence

ORD record
ord-3b7d027b8b1f4ee8b222a431fe14f948
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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