Anisole → 4'-Methoxyacrylophenone

HRID 1428449Notes

Reaction equation

HRID 1428449 reaction equation
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:12])[CH:10]=[CH2:11].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][C:4]([C:9](=[O:12])[CH:10]=[CH2:11])=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 7519AnisoleHCID 13140Acryloyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 240174'-MethoxyacrylophenoneYield 98.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Anisole (108 mg), acryloyl chloride (154 mg), and aluminium chloride (199 mg) were reacted in dichloromethane (1.5 mL) at from −20° C. to room temperature for 4 hours. The resultant was treated in the same manner as described in Example 1 to obtain the title compound (160 mg).

Workup

  1. additionThe resultant was treated in the same manner

Sources & evidence

ORD record
ord-f70513f3cdb842beab001b63b151afc8
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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