1-Fluoronaphthalene → HCID 46913484, compound

HRID 1428458Notes

Reaction equation

HRID 1428458 reaction equation
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[C:12](Cl)(=[O:15])[CH:13]=[CH2:14].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[F:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12](=[O:15])[CH:13]=[CH2:14])=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 94501-FluoronaphthaleneHCID 13140Acryloyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 46913484HCID 46913484, compoundYield 195%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-fluoronaphthalene (146 mg), acryloyl chloride (110 mg), and aluminium chloride (150 mg) were reacted in dichloromethane (1 mL) at from −15° C. to room temperature for 2 hours. The resultant was treated in the same manner as described in Example 1 to obtain the title compound (390 mg).

Workup

  1. additionThe resultant was treated in the same manner

Sources & evidence

ORD record
ord-8b496dbe5910410590f9268d1b9a9f7b
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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