Trifluoroacetic acid → HCID 66788310, compound

HRID 1428515Notes

Reaction equation

HRID 1428515 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][N:17]3[C:20]([CH2:23][CH:24]4[CH2:26][CH2:25]4)=[N:21][N:22]=[C:16]3[C:15]=2[CH3:27])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH:24]1([CH2:23][C:20]2[N:17]3[CH:18]=[CH:19][C:14]([CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[C:15]([CH3:27])[C:16]3=[N:22][N:21]=2)[CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66787770HCID 66787770, compound

Product 1

HCID 66788310HCID 66788310, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of D100 (0.207 g, 0.560 mmol) in dry DCM (3.5 ml), was added trifluoroacetic acid (1.01 ml). The mixture was stirred at r.t. for 2 h and then concentrated in vacuo. The residue was basified with NaOH 50% (aqueous solution) and extracted with DCM. The organic phase was separated, dried (Na2SO4) and concentrated in vacuo to yield intermediate D101 (0.149 g, 99%).

Workup

  1. concentrationconcentrated in vacuo
  2. extractionextracted with DCM
  3. customThe organic phase was separated
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a62fadf286054b03807dd15f4965efed
Source dataset
uspto-grants-2015_01
Patent number
US08937060B2

Reaction notes

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