反应详情

(4-Nitrophenyl)methanamine (715 mg, 4.7 mmol) was dissolved in pyridine (4 mL). The reaction mixture was added ethane sulfonyl chloride (0.58 mL, 6.11 mmol) and stirred for 1 h at room temperature. TLC showed complete consumption of starting material. The mixture was diluted with 1N HCl and extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated under reduced pressure. The crude was purified by column chromatography to give N-(4-nitrobenzyl)ethanesulfonamide (776 mg, 68%).

1. customconsumption of starting material
2. additionThe mixture was diluted with 1N HCl
3. extractionextracted with ethyl acetate
4. dry with materialThe extract was dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe crude was purified by column chromatography