反应详情

温度

0 °C

(4-Bromo-2-fluorophenyl)methanamine (924 mg, 4.53 mmol) was dissolved in pyridine and ethane sulfonyl chloride (0.82 mL, 8.60 mmol) was added to the solution at 0° C. The mixture was stirred for 1 h at 0° C. Then, the mixture was quenched with 1N HCl and extracted with ethyl acetate. Drying over magnesium sulfate and evaporation of the ethyl acetate and purified by column chromatography gave N-(4-bromo-2-fluorobenzyl)-ethanesulfonamide in pure form (1.06 g, 79%).

1. customThen, the mixture was quenched with 1N HCl
2. extractionextracted with ethyl acetate
3. dry with materialDrying over magnesium sulfate and evaporation of the ethyl acetate
4. custompurified by column chromatography