HCID 86679392, compound → HCID 86679393, compound

HRID 1428777Notes

Reaction equation

HRID 1428777 reaction equation
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]([CH2:8][NH:9][S:10]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C.O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:22]=[CH:21][C:7]([CH2:8][NH:9][S:10]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:18])([CH3:19])[CH3:17])(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

5

Reactant 1

HCID 86679392HCID 86679392, compound

Product 1

HCID 86679393HCID 86679393, compoundYield 98.1%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

10% Pd/C (7 mg) was added to a solution tert-butyl N-(4-nitrobenzyl)sulfamoyl-carbamate (65 mg) in ethanol and tetrahydrofuran and charged with H2. After stirring the reaction mixture for 6 h, the mixture was filtered using celite and evaporated in vacuo to obtain tert-butyl N-(4-aminobenzyl)sulfamoylcarbamate (58 mg, 98%).

Workup

  1. additioncharged with H2
  2. filtrationthe mixture was filtered
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-817a4eab10904174ab2bf4eda3b05e1c
Source dataset
uspto-grants-2015_01
Patent number
US08937092B2

Reaction notes

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