反应详情

A solution of 2-(3-fluoro-4-nitrophenyl)propanoic acid in methanol was added thionyl chloride (2.5 equiv.) at 0° C. and removed ice-bath. Reaction mixture was stirred at room temperature. After 2 h, dry over magnesium sulfate and evaporate solvent and purified by column chromatography (ethylacetate-hexane) to obtain methyl 2-(3-fluoro-4-nitrophenyl)propanoate.

1. customremoved ice-bath
2. customReaction mixture
3. dry with materialdry over magnesium sulfate
4. customevaporate solvent
5. custompurified by column chromatography (ethylacetate-hexane)