HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-(3-fluoro-4-nitrophenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(3-Fluoro-4-nitrophenyl)propanoic acid | HCID 13065229 | — |
| Product | Methyl 2-(3-fluoro-4-nitrophenyl)propanoate | HCID 13213768 | — |
Reaction Steps
A solution of 2-(3-fluoro-4-nitrophenyl)propanoic acid in methanol was added thionyl chloride (2.5 equiv.) at 0° C. and removed ice-bath. Reaction mixture was stirred at room temperature. After 2 h, dry over magnesium sulfate and evaporate solvent and purified by column chromatography (ethylacetate-hexane) to obtain methyl 2-(3-fluoro-4-nitrophenyl)propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937092B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-1d68dbff0d12452e8b47b5f6514e7591 |
| Source note | uspto-grants-2015_01 |