Methyl 2-(3-fluoro-4-nitrophenyl)propanoate → Methyl 2-(4-amino-3-fluorophenyl)propanoate

HRID 1428780Notes

Reaction equation

HRID 1428780 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]([CH3:16])[C:12]([O:14][CH3:15])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>[Pd].CO>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH:11]([CH3:16])[C:12]([O:14][CH3:15])=[O:13])=[CH:3][C:2]=1[F:1]

Participants

4

Reactant 1

HCID 13213768Methyl 2-(3-fluoro-4-nitrophenyl)propanoate

Product 1

HCID 13758007Methyl 2-(4-amino-3-fluorophenyl)propanoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10% Palladium on carbon is added to a solution methyl 2-(3-fluoro-4-nitrophenyl)propanoate in methanol and the mixture is charged with H2 (g). After stirring the reaction mixture for 6 h, the mixture is filtered using celite packed filter and purified by column chromatography to obtain methyl 2-(4-amino-3-fluorophenyl)propanoate.

Workup

  1. additionthe mixture is charged with H2 (g)
  2. filtrationthe mixture is filtered
  3. filtrationpacked filter
  4. custompurified by column chromatography

Sources & evidence

ORD record
ord-c79403282ab543c7a07a96c1cda069c7
Source dataset
uspto-grants-2015_01
Patent number
US08937092B2

Reaction notes

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