HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(3-fluoro-4-nitrophenyl)propanoate → Methyl 2-(4-amino-3-fluorophenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(3-fluoro-4-nitrophenyl)propanoate | HCID 13213768 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(4-amino-3-fluorophenyl)propanoate | HCID 13758007 | — |
Reaction Steps
10% Palladium on carbon is added to a solution methyl 2-(3-fluoro-4-nitrophenyl)propanoate in methanol and the mixture is charged with H2 (g). After stirring the reaction mixture for 6 h, the mixture is filtered using celite packed filter and purified by column chromatography to obtain methyl 2-(4-amino-3-fluorophenyl)propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937092B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-c79403282ab543c7a07a96c1cda069c7 |
| Source note | uspto-grants-2015_01 |