HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1428781Generated: November 1, 2026
Nitrogen → Methyl 2-(4-cyano-3-fluorophenyl)propanoate
https://huagongshe.com/reaction/1428781
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl 2-(3-fluoro-4-iodophenyl)propanoate | HCID 70855905 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Product | Methyl 2-(4-cyano-3-fluorophenyl)propanoate | HCID 58915206 | — |
Reaction Steps
Methyl 2-(3-fluoro-4-iodophenyl)propanoate, tetrakis(triphenylphosphine) palladium(0) and zinc cyanide are placed in dimethylformamide and charged with N2. The reaction mixture was stirred at 120° C. for 15 h and cooled to room temperature. The reaction mixture is filtered by celite packed filter, washed with ethyl acetate. After concentrate solvent, residue is purified on a silica gel column using ethylacetate-hexane as solvent system to give methyl 2-(4-cyano-3-fluorophenyl)propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08937092B2 |
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| Source dataset | uspto-grants-2015_01 |
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| ORD ID | ord-a740748b80e3458b804da76265de57a5 |
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| Source note | uspto-grants-2015_01 |
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