反应详情

温度

120 °C

Methyl 2-(3-fluoro-4-iodophenyl)propanoate, tetrakis(triphenylphosphine) palladium(0) and zinc cyanide are placed in dimethylformamide and charged with N2. The reaction mixture was stirred at 120° C. for 15 h and cooled to room temperature. The reaction mixture is filtered by celite packed filter, washed with ethyl acetate. After concentrate solvent, residue is purified on a silica gel column using ethylacetate-hexane as solvent system to give methyl 2-(4-cyano-3-fluorophenyl)propanoate.

1. temperaturecooled to room temperature
2. filtrationThe reaction mixture is filtered by celite
3. filtrationpacked filter
4. washwashed with ethyl acetate
5. concentrationAfter concentrate solvent, residue
6. customis purified on a silica gel column