2,6-Dimethylbenzoic acid → 2,6-Dimethylbenzoyl chloride

HRID 1428877Notes

Reaction equation

HRID 1428877 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:14])=O>CN(C=O)C>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([Cl:14])=[O:5]

Participants

4

Reactant 2

HCID 124392,6-Dimethylbenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 890962,6-Dimethylbenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

DMF (2 drops) was added to 2,6-dimethylbenzoic acid (0.100 g, 0.666 mmol) in thionyl chloride (0.50 mL, 6.9 mmol). The reaction mixture was stirred for 2 h and concentrated to yield the titled compound, which was used in the next step without further purification.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-a1cf56969b5045c1ba5b843b82426c89
Source dataset
uspto-grants-2015_01
Patent number
US08937078B2

Reaction notes

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