Water → 4-Chloro-6-methoxypyrimidine

HRID 1428935Notes

Reaction equation

HRID 1428935 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[CH:10]=[C:9](Cl)[N:8]=[CH:7][N:6]=1.O>CO>[Cl:4][C:5]1[CH:10]=[C:9]([O:2][CH3:1])[N:8]=[CH:7][N:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 709434,6-DichloropyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 10515094-Chloro-6-methoxypyrimidineYield 85.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8 g sodium methanolate was added to 10 g 4,6-dichlorpyrimidine in 100 mL methanol at 0° C. The reaction was stirred at RT over night. The mixture was added into water and extracted with ethylacetate. The organic layer was dried with magnesium sulfate and evaporated to give 8.34 g desired product. Rt: 0.97 min (method B), (M+H)+: 145

Workup

  1. extractionextracted with ethylacetate
  2. dry with materialThe organic layer was dried with magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-f9bd2fa595c6454a99cdd8cb173949cb
Source dataset
uspto-grants-2015_01
Patent number
US08937176B2

Reaction notes

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