HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Chloro-6-methoxypyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloro-6-methoxypyrimidine | HCID 1051509 | 85.9% |
Reaction Steps
8 g sodium methanolate was added to 10 g 4,6-dichlorpyrimidine in 100 mL methanol at 0° C. The reaction was stirred at RT over night. The mixture was added into water and extracted with ethylacetate. The organic layer was dried with magnesium sulfate and evaporated to give 8.34 g desired product. Rt: 0.97 min (method B), (M+H)+: 145
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937176B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f9bd2fa595c6454a99cdd8cb173949cb |
| Source note | uspto-grants-2015_01 |