HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(6-methoxypyrimidin-4-yl)piperazine-1-carboxylate | HCID 66569709 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride | HCID 45789016 | — |
Reaction Steps
9.8 g 4-(6-methoxy-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was stirred in 100 mL 4 mol/L HCl solution in dioxane for 4 h. The precipitate was filtered and dried to yield 8.1 g of the desired compound. Rt: 0.22 min (method B), (M+H)+: 195
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937176B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-503486cac4df400bbda736eb1d5c3a6d |
| Source note | uspto-grants-2015_01 |