Hydrochloric Acid → 4-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride

HRID 1428937Notes

Reaction equation

HRID 1428937 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:21][O:20][C:18]1[CH:19]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:15]=[CH:16][N:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66569709Tert-butyl 4-(6-methoxypyrimidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 457890164-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

9.8 g 4-(6-methoxy-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was stirred in 100 mL 4 mol/L HCl solution in dioxane for 4 h. The precipitate was filtered and dried to yield 8.1 g of the desired compound. Rt: 0.22 min (method B), (M+H)+: 195

Workup

  1. filtrationThe precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-503486cac4df400bbda736eb1d5c3a6d
Source dataset
uspto-grants-2015_01
Patent number
US08937176B2

Reaction notes

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