Sodium Hydroxide → HCID 86688151, compound

HRID 1428945Notes

Reaction equation

HRID 1428945 reaction equation
C([O:8][CH2:9][C:10]1[N:11]([CH2:23][CH3:24])[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH3:22])[CH:16]=2)[N:14]=1)C1C=CC=CC=1.[OH-].[Na+]>Cl>[CH2:23]([N:11]1[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH3:22])[CH:16]=2)[N:14]=[C:10]1[CH2:9][OH:8])[CH3:24]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86688149HCID 86688149, compound

Product 1

HCID 86688151HCID 86688151, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4 g 2-benzyloxymethyl-1-ethyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazole was stirred 24 h at 85° C. in 40 mL concentrated aqueous hydrochloride acid. The mixture was dropped in a cooled 10% aqueous sodium hydroxide solution. The precipitate was filtered, washed with water and dried at 50° C. to yield 2.8 g of the desired product. Rt: 0.60 min (method J), (M+H)+: 235

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried at 50° C.

Sources & evidence

ORD record
ord-1c39913f53b4449aa2d0dd34bfcf9897
Source dataset
uspto-grants-2015_01
Patent number
US08937176B2

Reaction notes

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