HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-(+)-Cysteine → Isopenicillin N
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-(+)-Cysteine | HCID 5862 | — |
| Reactant | L-Valine | HCID 6287 | — |
| Reactant | Penicillin G Potassium | HCID 23664709 | — |
| Product | Isopenicillin N | HCID 440723 | — |
Reaction Steps
The first two steps in the biosynthesis of penicillin in P. chrysogenum are the condensation of the three amino acids L-5-amino-5-carboxypentanoic acid (L-α-aminoadipic acid) (A), L-cysteine (C) and L-valine (V) into the tripeptide LLD-ACV, followed by cyclization of this tripeptide to form isopenicillin N. This compound contains the typical β-lactam structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726032 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-3bb66da6f37b43aebd4a5504e234b1f4 |
| Source note | uspto-grants-1998_03 |