HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 178493579, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Methoxy-6-[(4-methoxyphenyl)methoxy]-2-phenylpyrimidine | HCID 59312872 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | HCID 178493579 | HCID 178493579 | 83% |
Reaction Steps
4-Methoxy-6-(4-methoxybenzyloxy)-2-phenylpyrimidine was dissolved in a mixture of TFA:DCM (1:2, 30 ml). The mixture was stirred at RT for 2 h. NaHCO3 and DCM was added and the organic layer was separated off, dried, filtered and evaporated to give the title compound (1.04 g, 83%), MS (M+H)+203.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08937080B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-6a79ce39da5145c287e65807fb1e9dae |
| Source note | uspto-grants-2015_01 |