HRID1429157
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
Compound 10f (43 mg, 72.4 mmol), phenylboronic acid (13 mg, 109 μmol) and (PPh3)2PdCl2 (5 mg, 7.2 umol) were mixed in a microwave reaction vial and heated in the microwave at 120° C. for 20 min. The reaction mixture was then quenched by addition of citric acid (20 ml) and extracted 2 times with DCM (10 ml). The combined organic phases were washed with water (2×10 ml) and brine (10 ml), dried over MgSO4 and filtered. The solvent was removed in vacuo and the crude product was purified by preparative LC-MS which gave the title compound (5.9 mg, 13%), (ESI+)=636 (MH+).
WORKUP
后处理
- customThe reaction mixture was then quenched by addition of citric acid (20 ml)
- extractionextracted 2 times with DCM (10 ml)
- washThe combined organic phases were washed with water (2×10 ml) and brine (10 ml)
- dry with materialdried over MgSO4
- filtrationfiltered
- customThe solvent was removed in vacuo
- customthe crude product was purified by preparative LC-MS which