Dichloromethane → 3-hydroxy-N-[(2-methylpropan-2-yl)oxy]-4-[[4-[(2-methylquinolin-4-yl)methoxy]phenyl]sulfonylamino]piperidine-3-carboxamide

HRID 142922Notes

Reaction equation

HRID 142922 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][NH:6][C:7](=[O:8])[C:9]1([OH:45])[CH2:10][N:11]([C:38]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])[CH2:12][CH2:13][CH:14]1[NH:15][S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][c:22]([O:25][CH2:26][c:27]2[cH:28][c:29]([CH3:37])[n:30][c:31]3[cH:32][cH:33][cH:34][cH:35][c:36]23)[cH:23][cH:24]1.[Cl:53][CH2:54][Cl:55].[OH:46][C:47]([C:48]([F:49])([F:50])[F:51])=[O:52]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][NH:6][C:7](=[O:8])[C:9]1([OH:45])[CH2:10][NH:11][CH2:12][CH2:13][CH:14]1[NH:15][S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][c:22]([O:25][CH2:26][c:27]2[cH:28][c:29]([CH3:37])[n:30][c:31]3[cH:32][cH:33][cH:34][cH:35][c:36]23)[cH:23][cH:24]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178426780HCID 178426780, compound

Product 1

HCID 912198453-hydroxy-N-[(2-methylpropan-2-yl)oxy]-4-[[4-[(2-methylquinolin-4-yl)methoxy]phenyl]sulfonylamino]piperidine-3-carboxamide

Sources & evidence

ORD record
ord-1967bad243054ebda708ab6a12f1c7d9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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