反应详情

Hydrochloric acid (4 M in dioxane, 20 mL, 80 mmol) was added to a solution of tert-butyl 4-fluoro-4-phenylpiperidine-1-carboxylate (8.27 g, 29.6 mmol) in dioxane (10 mL). The reaction was stirred at ambient temperature for 4 hours. The reaction was concentrated to an oil. Ether was added, and the resulting solid was sonicated and then stirred vigorously overnight to provide a tan solid. The solid was filtered, rinsed with ether and dried under vacuum at 60° C. for 3 hours to provide 5.56 g (87%) of the titled product. MS (DCI) m/z 180 (M+H)+.

1. concentrationThe reaction was concentrated to an oil
2. additionEther was added
3. customthe resulting solid was sonicated
4. stirringstirred vigorously overnight
5. customto provide a tan solid
6. filtrationThe solid was filtered
7. washrinsed with ether
8. customdried under vacuum at 60° C. for 3 hours