Tetrahydrofuran → HCID 54902521, compound

HRID 1429228Notes

Reaction equation

HRID 1429228 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]([CH3:18])[CH2:15][CH:14]([CH3:19])[CH2:13]1.C1COCC1>[Ni].O>[CH3:18][CH:16]1[CH2:15][CH:14]([CH3:19])[CH2:13][N:12]([C:3]2[C:4]([F:11])=[CH:5][C:6]([NH2:8])=[CH:7][C:2]=2[F:1])[CH2:17]1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 66630106HCID 66630106, compound

Product 1

HCID 54902521HCID 54902521, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 962WaterSolvent

Procedure

1-(2,6-Difluoro-4-nitrophenyl)-3,5-dimethylpiperidine (14.01 g, 51.8 mmol) and THF (240 mL) were added to Raney-nickel 2800, water slurry (14.01 g, 239 mmol) in a 500 mL stainless steel pressure bottle. The mixture was stirred for 8 hours at 30 psi and room temperature. The mixture was filtered through a nylon membrane and concentrated to give the title compound.

Workup

  1. filtrationThe mixture was filtered through a nylon membrane
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-285a1f1fe3814f51b745b96f48b15d41
Source dataset
uspto-grants-2015_01
Patent number
US08937150B2

Reaction notes

Loading…