Mupirocin → HT-61

HRID 1429340Notes

Reaction equation

HRID 1429340 reaction equation
CC1(C)S[C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13](N)[C:14]3[CH:15]=[CH:16][C:17](O)=[CH:18][CH:19]=3)=O)[C:8](=O)N2[C@H]1C(O)=O.[CH2:26]1C(=O)[N:28]2[C@@H](C([O-])=O)/C(/O[C@H:27]12)=C/CO.[K+].C[C@@H:42]([C@@H](O)C)[C@@H:43]1O[C@H:44]1[CH2:46][C@@H:47]1[C@@H](O)[C@@H:51](O)[C@H:50]([CH2:55]/[C:56](/[CH3:72])=C/C(OCCCCCCCCC(O)=O)=O)[O:49][CH2:48]1.[CH:76]1C(NC(NC(NCCCCCCNC(NC(NC2C=CC(Cl)=CC=2)=N)=N)=N)=N)=CC=C(Cl)[CH:77]=1.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O>>[CH3:26][C:27]1[C:5]2[CH2:76][CH2:77][N:10]([CH2:11][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[C:8]2[CH:51]=[C:50]([O:49][C:48]3[CH:42]=[CH:43][CH:44]=[CH:46][CH:47]=3)[CH:55]=[CH:56][C:72]=2[N:28]=1

Participants

4

Reactant 3

HCID 446596MupirocinHCID 23665637Amoxicillin mixture with Clavulanate potassiumHCID 178512161HCID 178512161, compound

Product 1

HCID 16727326HT-61

Procedure

Co-amoxiclav (1000/200 mg infusion, GlaxoSmithKline) was purchased from St George's NHS Hospital, London. Mupirocin was purchased from Sigma Aldrich Ltd (Poole, Dorset, UK). Chlorhexidine gluconate was purchased from Sigma Aldrich Ltd (Poole, Dorset, UK). 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline (in hydrochloride salt form) was provided by Helperby Therapeutics.

Sources & evidence

ORD record
ord-223bb529bd66420bbe4e0a1c09621819
Source dataset
uspto-grants-2015_01
Patent number
US08940723B2

Reaction notes

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