HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1429363Generated: November 3, 2026
Aluminium lithium hydride → tert-Butyl(1-(4-bromophenyl)-3-((2-(hydroxymethyl)benzyl)oxy)propan-2-yl)carbamate
https://huagongshe.com/reaction/1429363
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Methyl 2-((3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propoxy)methyl)-benzoate | HCID 67382431 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | tert-Butyl(1-(4-bromophenyl)-3-((2-(hydroxymethyl)benzyl)oxy)propan-2-yl)carbamate | HCID 123944090 | 95.5% |
Reaction Steps
To a solution of compound 3g (5 g, 10 mmol) in dry ether (80 mL) was added slowly LiAlH4 (1M in THF, 15.7 mL, 15.7 mmol) at 0° C. The mixture was stirred at 0° C. for 30 min. Then the mixture was quenched with water (1 mL) under vigorous stirring. The precipitate was removed by filtration and the filtrate was concentrated in vacuo to give 3h as a white solid (4.3 g, 92% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08940722B2 |
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| Source dataset | uspto-grants-2015_01 |
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| ORD ID | ord-388502bbe1194de1ace1243f2daa2972 |
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| Source note | uspto-grants-2015_01 |
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