HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt | HCID 67382252 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine | HCID 67417363 | 86% |
Reaction Steps
A mixture of compound 3k (1.6 g, 3.9 mmol) and K2CO3 (1.6 g, 12 mmol) in dry THF (30 mL) was stirred at rt overnight. LCMS indicated the total consumption of compound 3k. The reaction mixture was filtered and the filtrate was evaporated in vacuum to give 3l as a white solid (1.1 g, 86% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940722B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-171454f8bf764c998f04d306ce529fd9 |
| Source note | uspto-grants-2015_01 |