Potassium Carbonate → (R)-4-Allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

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Reaction Steps

To a solution of compound 18k (2.0 g, 7.0 mmol) in EtOH (20 mL) was added K2CO3 (4.8 g, 35.0 mmol) portionwise. The mixture was heated to reflux for 2 h to complete the reaction. The reaction mixture was cooled down to rt and concentrated under reduced pressure to give compound 18l (1.2 g, 84% yield), which was used without purification. LCMS (m/z): 204.1 (MH+).

Provenance & Evidence