HCID 68233567, compound → HCID 67386725, compound

HRID 1429397Notes

Reaction equation

HRID 1429397 reaction equation
[OH:1][CH:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3]/[CH:4]=[CH:5]/[C:6]1[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]>CO.[Pd]>[OH:1][CH:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][CH2:4][CH2:5][C:6]1[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 1

HCID 68233567HCID 68233567, compound

Product 1

HCID 67386725HCID 67386725, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 30c (2.59 g, 8.75 mmol) in MeOH (100 mL) was hydrogenated using 10% Pd/C (0.93 g, 0.88 mmol) as catalyst at atmospheric pressure overnight. The catalyst was removed by filtration, and the solution was evaporated at reduced pressure to afford the desired product (2.27 g, 97% yield).

Workup

  1. customat atmospheric pressure overnight
  2. customThe catalyst was removed by filtration
  3. customthe solution was evaporated at reduced pressure

Sources & evidence

ORD record
ord-6625c93612de4e5d96df1cdbc823405a
Source dataset
uspto-grants-2015_01
Patent number
US08940722B2

Reaction notes

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