HCID 86677164, compound → HCID 67382638, compound

HRID 1429400Notes

Reaction equation

HRID 1429400 reaction equation
[N:1]([CH:4]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11])=[N+]=[N-]>CO.[Pd]>[NH2:1][CH:4]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:5][CH2:6][CH2:7][C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 1

HCID 86677164HCID 86677164, compound

Product 1

HCID 67382638HCID 67382638, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 30f (crude 7.7 mmol) in MeOH (40 mL) was hydrogenated using 10% Pd/C (817 mg, 0.77 mmol) as catalyst at atmospheric pressure overnight. The catalyst was removed by filtration, and the solution was evaporated at reduced pressure to afford the crude desired product as yellow oil, which was used without further purification in the next step.

Workup

  1. customat atmospheric pressure overnight
  2. customThe catalyst was removed by filtration
  3. customthe solution was evaporated at reduced pressure

Sources & evidence

ORD record
ord-8433114c981241d9a09612356debbe2f
Source dataset
uspto-grants-2015_01
Patent number
US08940722B2

Reaction notes

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