反应详情

To a solution of ethyl 2-(p-tolyloxy)acetate (200 mg, 1 mmol) in EtOH (10 ml) was added 10% NaOH solution (10 ml) at 26° C. The mixture was stirred for 30 min, concentrated then water (20 mL) added to it before washing with ethyl acetate (2×20 mL). The aqueous layer was acidified with 2N HCL until pH 3 and extracted with EA (2×20 ml). The organic layer was washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

1. concentrationconcentrated
2. additionwater (20 mL) added to it
3. washbefore washing with ethyl acetate (2×20 mL)
4. extractionextracted with EA (2×20 ml)
5. washThe organic layer was washed with brine (30 mL)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated