反应详情

To a solution of 4-methoxyphenol (500 mg, 4.03 mmol) in CH3CN (10 mL) was added ethyl 2-bromo-2-methylpropanoate (807 mg, 4.84 mmol) and K2CO3 (3 g, 21.7 mmol) at 25° C. The mixture was refluxed for 16 h. The mixture was then diluted with water (100 mL), extracted with ethyl acetate (2×50 mL) and the combined organic layers washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

1. temperatureThe mixture was refluxed for 16 h
2. extractionextracted with ethyl acetate (2×50 mL)
3. washthe combined organic layers washed with brine (30 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated