反应详情

温度

90 °C

8-(benzyloxy)quinolin-2-ol (6.6 g, 26.3 mmol) was dissolved in POCl3 (50 mL). The mixture was stirred at 90° C. for 16 h. The POCl3 was evaporated and to the residue was added EtOAc (100 mL) and the solution was washed with a.q. NaHCO3 (80 mL) and H2O (80 mL). The EtOAc was removed under vacuum to give the desired compound (6.0 g, yield 85%). LCMS (m/z): 270.1 [M+H]+

1. customThe POCl3 was evaporated and to the residue
2. additionwas added EtOAc (100 mL)
3. washthe solution was washed with a.q
4. customThe EtOAc was removed under vacuum