1-Propanesulfonyl chloride, 2-methyl- → 6-(1-(Isobutylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole

HRID 1429528Notes

Reaction equation

HRID 1429528 reaction equation
[CH2:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[S:18][C:19]4[CH:25]=[C:24]([C:26]5[CH2:27][CH2:28][NH:29][CH2:30][CH:31]=5)[CH:23]=[CH:22][C:20]=4[N:21]=3)[CH2:12][CH2:11]2)=[N:8][CH:9]=1)[CH2:2][CH3:3].[CH3:32][CH:33]([CH3:39])[CH2:34][S:35](Cl)(=[O:37])=[O:36]>>[CH2:34]([S:35]([N:29]1[CH2:28][CH:27]=[C:26]([C:24]2[CH:23]=[CH:22][C:20]3[N:21]=[C:17]([O:16][CH:13]4[CH2:14][CH2:15][N:10]([C:7]5[N:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][N:6]=5)[CH2:11][CH2:12]4)[S:18][C:19]=3[CH:25]=2)[CH2:31][CH2:30]1)(=[O:37])=[O:36])[CH:33]([CH3:39])[CH3:32]

Participants

3

Reactant 2

HCID 1822361-Propanesulfonyl chloride, 2-methyl-HCID 674627952-(1-(5-Propylpyrimidin-2-yl)piperidin-4-yloxy)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazole

Product 1

HCID 545964016-(1-(Isobutylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole

Procedure

Example 11 was prepared from Compound 1E and 2-methylpropane-1-sulfonyl chloride in a similar manner to the procedure described in Example 1. LCMS (M+H)+=556.

Sources & evidence

ORD record
ord-ffdaff941f724ac9a408b86b5aa8b507
Source dataset
uspto-grants-2015_01
Patent number
US08940716B2

Reaction notes

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