Hydrochloric Acid → 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoic acid

Participants

Reaction Steps

To a solution of methyl 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoate (Compound 47A, 268 mg, 0.447 mmol) in THF (3 mL) was added sat. aq. lithium hydroxide (1 mL). The reaction mixture was stirred at rt for 6 h. The reaction mixture was neutralized with cool aq. HCl (1 N) and extracted with CH2Cl2 (3×3 mL). The combined organic layers were washed with brine, dried (Na2SO4), filtered, and concentrated. The crude product was recrystallized from 10% water in CH3CN to afford 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoic acid (218 mg, 0.354 mmol, 79% yield) as a white solid. 1H NMR (500 MHz, CDCl3) δ ppm 8.25 (br. s., 2H), 7.60-7.66 (m, 2H), 7.39 (dd, J=8.5, 1.9 Hz, 1H), 6.01-6.12 (m, 1H), 5.43-5.53 (m, J=7.3, 3.6, 3.6, 3.4 Hz, 1H), 4.17-4.28 (m, 2H), 3.98-4.07 (m, 2H), 3.60 (t, J=5.8 Hz, 2H), 3.07-3.15 (m, 2H), 2.68 (d, J=1.7 Hz, 2H), 2.58-2.64 (m, 2H), 2.46 (t, J=7.6 Hz, 2H), 2.10-2.26 (m, 5H), 1.95-2.08 (m, 2H), 1.50-1.66 (m, 4H), 0.96 (t, J=7.4 Hz, 3H). LCMS (m/z)=586 (M+H)+.

Provenance & Evidence