Methyl 3-(chlorosulfonyl)propanoate → Methyl 3-(4-(2-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)propanoate

HRID 1429589Notes

Reaction equation

HRID 1429589 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([O:14][C:15]3[S:16][C:17]4[CH:23]=[C:22]([C:24]5[CH2:25][CH2:26][NH:27][CH2:28][CH:29]=5)[CH:21]=[CH:20][C:18]=4[N:19]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.Cl[S:31]([CH2:34][CH2:35][C:36]([O:38][CH3:39])=[O:37])(=[O:33])=[O:32]>>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([O:14][C:15]3[S:16][C:17]4[CH:23]=[C:22]([C:24]5[CH2:25][CH2:26][N:27]([S:31]([CH2:34][CH2:35][C:36]([O:38][CH3:39])=[O:37])(=[O:33])=[O:32])[CH2:28][CH:29]=5)[CH:21]=[CH:20][C:18]=4[N:19]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 4962888Methyl 3-(chlorosulfonyl)propanoateHCID 712699382-(1-(5-Methylpyrazin-2-yl)piperidin-4-yloxy)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazole

Product 1

HCID 71269985Methyl 3-(4-(2-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)propanoate

Procedure

Compound 50D was prepared from Compound 50C and methyl 3-(chlorosulfonyl)propanoate in a similar manner to the procedure described for Compound Example 16.

Sources & evidence

ORD record
ord-246d2f8246b84a08a0a8a3b0b82aef12
Source dataset
uspto-grants-2015_01
Patent number
US08940716B2

Reaction notes

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