Water → 5-(1,1-Difluoroethyl)pyrazine-2-carboxylic acid

HRID 1429625Notes

Reaction equation

HRID 1429625 reaction equation
[F:1][C:2]([C:5]1[N:6]=[CH:7][C:8]([C:11]([O:13]C)=[O:12])=[N:9][CH:10]=1)([F:4])[CH3:3].O.O.[OH-].[Li+]>O1CCOCC1>[F:1][C:2]([C:5]1[N:6]=[CH:7][C:8]([C:11]([OH:13])=[O:12])=[N:9][CH:10]=1)([F:4])[CH3:3]

Participants

5

Reactant 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 66869779Methyl 5-(1,1-difluoroethyl)pyrazine-2-carboxylate

Product 1

HCID 668695495-(1,1-Difluoroethyl)pyrazine-2-carboxylic acidYield 19.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methyl 5-(1,1-difluoroethyl)pyrazine-2-carboxylate (0.65 g, approx. purity 85%) was dissolved in dioxan (2 mL) and water (2 mL) was added, followed by lithium hydroxide monohydrate (54 mg, portionwise). After stirring at RT for 90 mins, the mixture was concentrated to 2 mL and Et2O (20 mL) added. The mixture was then extracted with NaOH (1 N, aq., 20 mL), and the aqueous portions acidified with 6N HCl to pH 2. The aqueous portion was then extracted with EtOAc, dried over MgSO4 and evaporated to afford the title compound as a white solid (119 mg). 1H NMR (400 MHz, CDCl3) δ ppm 2.11 (t, J=18.8 Hz, 3 H), 9.01 (d, J=1.3 Hz, 1 H), 9.47 (d, J=1.3 Hz, 1 H)

Workup

  1. concentrationthe mixture was concentrated to 2 mL and Et2O (20 mL)
  2. additionadded
  3. extractionThe mixture was then extracted with NaOH (1 N, aq., 20 mL)
  4. extractionThe aqueous portion was then extracted with EtOAc
  5. dry with materialdried over MgSO4
  6. customevaporated

Sources & evidence

ORD record
ord-96e9de64570046828cdbb076ed14b267
Source dataset
uspto-grants-2015_01
Patent number
US08940734B2

Reaction notes

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