Isopropanol hydrochloride → HCID 59805851, compound

HRID 1429658Notes

Reaction equation

HRID 1429658 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[N:8]=[N:7][C:6]([NH:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[CH:5][CH:4]=1.Cl.C(O)(C)C>CO>[NH:13]1[CH2:14][CH2:15][CH:10]([NH:9][C:6]2[N:7]=[N:8][C:3]([C:2]([F:24])([F:23])[F:1])=[CH:4][CH:5]=2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 21912024Isopropanol hydrochlorideHCID 59805854HCID 59805854, compound

Product 1

HCID 59805851HCID 59805851, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of D1 (7.06 g, 20.4 mmol) and hydrochloric acid/isopropanol (6N, 100 ml) in methanol (100 ml) was stirred at room temperature for 2 h. After this period, solvents were evaporated in vacuo and the residue triturated with acetonitrile. The solid product was filtered off and dried to give D2 as the di-hydrochloride salt (6.05 g, 95%). C10H13F3N4 requires 246; Found 247 (MH+)

Workup

  1. waitAfter this period
  2. customsolvents were evaporated in vacuo
  3. customthe residue triturated with acetonitrile
  4. filtrationThe solid product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-7bfffea49daf4a29a768380ffcc3aadd
Source dataset
uspto-grants-2015_01
Patent number
US08940743B2

Reaction notes

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